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En ensayos clnicos como SURPASS y SURMOUNT, la tirzepatida ha mostrado reducciones significativas de hemoglobina A1c (hasta 2.0-2.5% con dosis de 15 mg) y prdida de peso sustancial (15-22% del peso corporal inicial en estudios de 72 semanas), adems de mejoras en factores de riesgo cardiometablico como presin arterial y perfil lipdico

Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent

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Conversely a decrease in cellular cholesterol levels will increase SREBP2 expression resulting in an increase in LDL receptor activity and an increase in miR-33, which will result in a decrease in LXR activity, decreased expression of ABCA1 and ABCG1, and a reduction in cholesterol efflux